Research Associate I/II Research Associate (Upstream Process Development)

4D Molecular Therapeutics (4DMT), located in Emeryville, is a global leader in gene therapy product research and development using scientific innovation to unlock the full potential of gene therapy for patients with genetic diseases. At 4DMT, our goal is to design and develop transformative gene therapy products using our proprietary adeno-associated virus (AAV) variants platform to treat serious unmet medical conditions. We seek a talented and passionate Research Associate I/II to join our leading-edge Upstream Process Development team in designing manufacturing processes and novel AAV vectors.

Your creativity and innovative design, development and execution expertise in cell culture and scale-up technologies will be critical to helping us take 4DMT to the next level. Your work will directly impact both Process Development and Manufacturing. This role will require close collaboration with the Analytical Sciences & Bioinformatics (ASB) team.

4DMT is at the forefront of cutting-edge science and technology with proprietary AAV vectors that deliver transgene payloads to the right place for patients. This is an opportunity to join a well-funded, rapidly growing pre-IPO company as a key member of the process development team. You will be involved in the build-out for an expanded process development laboratory and have the opportunity to work on numerous products across multiple therapeutic areas. The diverse nature of our AAV vectors makes this position ideal for scientists looking to be on the cusp of scientific innovation, with much work to be done to advance the field to help accelerate the delivery of high value therapeutics to patients.  Moreover, you will have opportunities to present and publish as well as to make important contributions to regulatory filings for novel therapeutics.

Major Responsibilities:

  • Design and execute production studies leveraging 4DMT’s vector platform processes. Collaborate with process & analytical teams to screen and evaluate drug candidates across a range of indications.
  • Draft and update batch records, electronic lab notebooks (ELN), standard operating procedures and technical reports. Responsible for documentation that is IND-supporting and will be communicated to relevant internal/external stakeholder &/or regulatory parties.
  • Document, consolidate, interpret and communicate scientific findings with internal/external teams.
  • Contribute to a culture that embraces continuous learning, improvement and innovation. Can work with others to expand their technical skill base and deepen their gene therapy expertise. Work cross-functionally with downstream process development and analytical teams to generate and characterize AAV material across a range of therapeutics doses.
  • Maintains a current awareness and contributes to current scientific literature; actively applies new concepts and technologies.
  • Supports research initiatives such as new technology development and continuous improvement projects.

Knowledge & Skills:

  • BS with 1-3 years or MS with 0-2 years of experience of experience in process development, cell culture and/or viral production. Degree in Bioengineering, Biology, Biochemistry, Virology, or related field.
  • Experience with both adherent and suspension cell culture, maintenance and optimization. Technical skills in small and large-scale viral production a plus.
  • Strong organizational, analytical, problem-solving and multi-tasking skills. Excellent organizational skills and attention to detail in the lab.
  • Strong communication skills, both written and oral, with demonstrated ability to present ideas and information and data effectively in one on one discussions and team meetings. Ability to work independently and in a team environment.
  • Working knowledge of GMP & GDP is a plus.

Qualified candidates may submit a resume and cover letter to jobs@4dmt.com