Foundations and Advocacy Groups

Choroideremia Research Foundation (CRF)

In partnership with the Choroideremia Research Foundation, 4DMT seeks to develop a gene therapy product optimized for intravitreal administration to treat Choroideremia.

4DMT is conducting a Natural History Study for Choroideremia (CHM).

Natural History Studies track disease progression and are an essential first step in developing efficient clinical stages of testing in rare diseases. The purpose of this study is to evaluate disease progression as well as determine the feasibility of measuring endpoints for subsequent clinical trials in the hopes of providing medical benefit through gene therapy to all choroideremia patients and their families.

Two clinical sites are actively recruiting for the study:

  • Retina Foundation of the Southwest, Dallas, Texas (Principal Investigator Dr. David Birch). For eligibility information, contact  (214) 363-3911 ext. 114 or 116.
  • Retina Vitreous Associates of Los Angeles (“LA Retina” – Principal Investigator Dr. David Liao). For eligibility information, contact the Clinical Trial Department at (310) 289-2478.

This website will be updated as additional study sites open throughout the United States.

Eligibility requirements include but are not limited to: participants must be male, age 14 years or older, and have a CLIA Certified Genetic Diagnosis with visual acuity ≥ 20/200 or better.

Study participation requirements:

Attend Study Site Visits

  • An initial screening visit followed by a visit every 6 months, for 24 months for a total of 5 visits

Assessments Include

  • Medical history review
  • Visual and eye exam
  • Photography and imaging

Email Questions to

For more information about Choroideremia, visit the Choroideremia Research Foundation (CRF) online. Additional clinical trial information including contact numbers may be found at, NCT 02994368.

Saturday April 22, 2017, Country Inn and Suites, Brookfield, Wisconsin. Join the CRF for a free, one day seminar / meet and greet for all choroideremia patients and family members. This family friendly event will include speakers from the choroideremia patient community who will provide the latest updates on current and upcoming research, studies, clinical trials, free genetic testing and low vision resources.

Registration is free, lunch and refreshments will be provided.  Discounted hotel rates are available for this event for those who wish to come early or stay beyond. Visit for more information and to register.

Will this meeting help you and your family members?

This event will bring to attendees the spirit of family and hope that we have come to know. You will also receive information on CHM research and therapy development advances and how to prepare to participate in clinical trials and studies.

Looking forward to seeing you in Wisconsin!